Endometrial cancer
| PAG Title | Endometrial cancer |
| PAG ID | WAG000192 |
| Type | P |
| Source Link |  KEGG |
| Publication Reference | NA |
| PAG Description | Endometrial cancer (EC) is the most common gyecological maligncy and the fourth most common maligncy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in D-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification. |
| Species | Homo sapiens |
| nCoCo Score | 4,291 |
| Base PAG ID | WAG000192 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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